Bone and soft tissue sarcomas represent about 7-12% of all pediatric cancer and are aheterogeneous group of tumors arising in connective tissues embryologically derived fromthe mesenchyme. For some of these tumors relapse and mortality rates are stillsignificantly high. Therefore, further studies are needed to better understandpathogenetic processes underlying sarcomas to offer new and more effective treatments.Next generation sequencing (NGS) has opened new frontiers for cancer research allowing toidentify somatic or constitutional mutations known or yet unknown with the aim to betterunderstand carcinogenesis. The establishment of the genomic profile of the tumor couldalso help clinicians to personalize patients treatment based on their genetic andmolecular alterations.
Other: observation and biopsy
biopsy
Inclusion Criteria:
1. Patients with histologically confirmed Osteosarcoma, Ewing Sarcoma or Synovial
Sarcoma at first diagnosis.
2. Patients with confirmed relapsed/refractory Osteosarcoma, Ewing Sarcoma or Synovial
Sarcoma
3. Written informed consent signed by the patient, or parents or legal representative
to perform molecular analysis of the tumor sample.
4. Patients aged ≤24 years
5. Pathological review of tumor samples.
6. Availability of fresh tumor sample from newly diagnosed or relapsed/refractory
cancer and 10 ml of EDTA peripheral blood sample. Centralization of
paraffin-embedded tumor sample might be optional.
Exclusion Criteria:
-
1. Known history of active HIV, HCV, or HBV infection 2. Presence of a condition
or abnormality that in the opinion of the Investigator would compromise the
safety of the patient undergoing surgery biopsy or the quality of the data.
AOU Città della Salute e della Scienza di Torino - Presidio Infantile Regina Margherita
Torino, Turin, Italy
Istituto Ortopedico Rizzoli
Bologna, Italy
Policlinico S.Orsola-Malpighi
Bologna, Italy
Azienda ospedaliero-universitaria Meyer
Firenze, Italy
Istituto Giannina Gaslini
Genova, Italy
Istituto Nazionale Tumori
Milan, Italy
Presidio Ospedaliero Gaetano Pini | ASST Pini-CTO
Milan, Italy
Fondazione I.R.C.C.S. Policlinico San Matteo
Pavia, Italy
Istituti fisioterapici Ospitalieri - Istituto Tumori Regina Elena e Istituto Dermatologico San Gallicano
Roma, Italy
IRCCS materno infantile Burlo Garofolo
Trieste, Italy
Elisa Tirtei, MD
00390113135171
etirtei@cittadellasalute.to.it
Celeste Cagnazzo, PhD
celeste.cagnazzo@unito.it
Franca Fagioli, MD, Principal Investigator
A.O.U. Città della Salute e della Scienza