There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of individuals with vs without COVID-19 after being exposed to infected cases. Additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the Montreal Cognitive Assessment (MoCA) questionnaire.
Genetic: Whole exome sequencing
MoCA survey to evaluate cognitive function in COVID-19 positive cases with vs without neurological symptoms
Other Name: Cognitive function
Inclusion Criteria:
1. Male or female over 18 years of age at the time of enrollment
2. Have symptoms of COVID-19 (with or without hospitalization) or contact history
3. Willing to undergo nasopharyngeal swab test for viral-RNA at baseline (in
non-hospitalized cases) and the MoCA survey at baseline and 1-month follow-up
Exclusion Criteria:
1. Unwilling to provide informed consent
2. MoCA score ≤17 at baseline
3. Patients with clinical diagnosis of dementia
4. Impaired consciousness
Texas Cardiac Arrhythmia Institute
Austin, Texas, United States
Investigator: Sanghamitra Mohanty
mitra1989@gmail.com
Sanghamitra Mohanty
5127842651
mitra1989@gmail.com
Bryan MacDonald
5125447252
Andrea Natale, Principal Investigator
Texas Cardiac Arrhythmia Institute, St.