Official Title
Genetic Mechanisms Underlying SARS-CoV-2 Infection and the Impact of COVID-19 on Cognitive Function
Brief Summary

There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of individuals with vs without COVID-19 after being exposed to infected cases. Additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the Montreal Cognitive Assessment (MoCA) questionnaire.


Genetic: Whole exome sequencing
MoCA survey to evaluate cognitive function in COVID-19 positive cases with vs without neurological symptoms
COVID-19 negative
COVID-19 positive
Other Name: Cognitive function

Eligibility Criteria

Inclusion Criteria: 1. Male or female over 18 years of age at the time of enrollment 2. Have symptoms of COVID-19 (with or without hospitalization) or contact history 3. Willing to undergo nasopharyngeal swab test for viral-RNA at baseline (in non-hospitalized cases) and the MoCA survey at baseline and 1-month follow-up

Exclusion Criteria: 1. Unwilling to provide informed consent 2. MoCA score ≤17 at baseline 3. Patients with clinical diagnosis of dementia 4. Impaired consciousness

Eligibility Gender
Eligibility Age
Minimum: 18 Years
United States

Texas Cardiac Arrhythmia Institute
Austin, Texas, 78705


Investigator: Sanghamitra Mohanty


Sanghamitra Mohanty

Bryan MacDonald

Andrea Natale
Principal Investigator
Texas Cardiac Arrhythmia Institute, St.

Texas Cardiac Arrhythmia Research Foundation
NCT Number
MeSH Terms