Official Title
Extracorporeal Membrane Oxygenation (ECMO) as a Therapeutic Option in Severe Form of COVID-19: a Nationwide Cohort Study
Brief Summary

The role of ECMO in the treatment of patients with severe COVID-19 (Acute Respiratory Distress Syndrome (ARDS) and/or acute refractory heart failure) is not yet known. The present study will aim to report the results of the ECMO management of the most severe forms of COVID-19 through the first French ECMO registry.

Detailed Description

The main objective of this study is to evaluate the hospital survival of COVID-19 patients
supported by venovenous or venoarterial ECMO in a multicenter registry.

The secondary objectives are to describe the characteristics of COVID-19 patients who have
received ECMO support, to identify the risk factors associated with hospital mortality, to
analyze the outcomes after ECMO weaning including survival at day 28 and day 90, and to
analyze the utility of a circulatory support mobile unit in a severe pandemic

Inclusions are both prospective and retrospective in order to collect data over the whole
pandemic

Unknown status
ARDS Related to Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 2
Acute Refractory Heart Failure Related to SARS-CoV 2
Eligibility Criteria

Inclusion Criteria:

- All COVID-19 patients, adults or children,

- Tested positive by RT-PCR for SARS-CoV2 (nasopharyngeal swabs, sputum, endotracheal
aspiration, bronchoalveolar lavage or stool sample) and / or with a diagnosis made on
chest CT findings,

- Supported by venovenous or venoarterial ECMO

Exclusion Criteria:

- Temporary legally protected Adults over a set period or waiting for protection
supervision, guardianship

- Patients or proxies who express their opposition to study participation

Eligibility Gender
All
Eligibility Age
Minimum: N/A ~ Maximum: N/A
Countries
France
Locations

Angers University Hospital
Angers, France

Besançon Hospital
Besançon, France

Brest university Hospital
Brest, France

Caen University Hospital
Caen, France

Clermont ferrand University hospital
Clermont-Ferrand, France

APHP Henri Mondor Paris University Hospital
Créteil, France

Dijon University Hospital
Dijon, France

Vendée Hospital
La Roche-sur-Yon, France

Grenoble University Hospital
La Tronche, France

APHP Kremli Bicetre Paris University Hospital
Le Kremlin-Bicêtre, France

Marie Lannelongue Hospital
Le Plessis-Robinson, France

Lens Hospital
Lens, France

Lille University Hospital
Lille, France

Limoges University Hospital
Limoges, France

Clinique de la Sauvegarde
Lyon, France

Lyon University Hospital
Lyon, France

Marseille Européen Hospital
Marseille, France

APHM la Timone- Marseille University Hospital
Marseille, France

Clairval Hospital
Marseille, France

Metz University Hospital
Metz, France

Montpellier University Hospital
Montpellier, France

Emile Muller Hospital
Mulhouse, France

Nancy University Hospital
Nancy, France

Nantes University Hospital
Nantes, France

Ambroise Paré Hospital
Neuilly-sur-Seine, France

Nimes University Hospital
Nimes, France

Institut Mutualiste Montsouris
Paris, France

APHP Hopital Européen Georges Pompidou - Paris University Hospital
Paris, France

APHP necker Paris University Hospital
Paris, France

APHP Bichat - Paris University Hospital
Paris, France

APHP La Pitié Salpêtrière Paris University Hospital
Paris, France

Bordeaux University Hospital
Pessac, France

Poitiers University hospital
Poitiers, France

Reims University hospital
Reims, France

Rennes University hospital
Rennes, France

Rouen University Hospital
Rouen, France

Saint brieuc Hospital
Saint brieuc, France

La Réunion University Hospital
Saint-Denis, France

Saint Nazaire Hospital
Saint-Nazaire, France

Saint Etienne University Hospital
Saint-Étienne, France

Strasbourg University Hospital
Strasbourg, France

Toulouse University Hospital - Rangueil Hospital
Toulouse, France

Tours University Hospital
Tours, France

Bretagne Atlantique Hospital
Vannes, France

Contacts

Cécile Ferragu
0299282555
cecile.ferragu@chu-rennes.fr

DRI
0299282555
dri@chu-rennes.fr

Rennes University Hospital
NCT Number
Keywords
ECMO
Covid-19
SARS-CoV2
ARDS
Myocarditis
heart failure
MeSH Terms
Coronavirus Infections
Severe Acute Respiratory Syndrome
Heart Failure