The trial was designed to assess the effect of daily dose of 300 mg omega-3 supplements for 2 months on the selected interleukins levels in uninfected people with Covid-19.
Omega-3 Fatty Acids (Omega-3) are long poly unsaturated fatty acids that can be found in
plants and fish, its refer to a group composed of three type of fatty acids called:
Eicosapentaenoic acid (EPA), Alpha-linoleic acid (ALA), and Docosahexaenoic acid (DHA) . The
health promoting effect of n-3FA may be due to immune modulating and anti-inflammatory
actions . The anti-inflammatory properties of n-3FA are used for treatment of the
inflammatory diseases such as irritable bowel syndrome, rheumatoid arthritis, eczema, and
psoriasis . Many studies reported a significant reduction in the risk of cancers in breast,
prostate, ovaries with supplementation of n-3FA (Larsson et al. 2004) .However, high-doses
omega-3 supplements such as 1000 mg/day are widely spread in community pharmacies in Jordan .
Currently , community pharmacy around the world are facing the challenge of increased demand
for care of uninfected people with Covid -19. Accordingly , the current randomized clinical
trial was designed to evaluate the effect of daily 300 mg of omega 3-FA supplements on the
immune health status of uninfected people with Covid-19 as a part of as a part of preventive
health care .
Therefore , this RCT aims to assess whether regular daily dose of regular daily dose of omega
3-FA (300 mg) for 2 months supplementation against COVID-19 infection as a part of preventive
treatment protocol in uninfected Jordanian peoples. The investigators hypothesize that the
regular dose of omega 3-FA (300 mg) /day for 2 months will significantly change immune
responses compared with the control group.
Dietary Supplement: 300 mg of omega3-FA
The participant will receive 1,000 mg of wild salmon and fish oil complex once daily, which contains 300 mg of omega3-FA.
Baseline and follow-up serum levels of IL-1,IL-6, and TNF will be measured.
Other Name: n-3FA
Inclusion Criteria:
- Inclusion criteria included males and females in the age range of 30-66 years without
a medical diagnosis of COVID-19 infection.
Exclusion Criteria:
- Exclusion criteria included males or females diagnosed with any chronic immune
problems, including autoimmune diseases, chronic or severe infections.
- Pregnant, breastfeeding, and females using hormonal contraceptives were also excluded.
Mahmoud S Abu-Samak
Amman, Jordan