The effect of Weekly 50,000 IU vitamin D3 supplements on the serum levels of selected cytokines involved in cytokine storm of Covid-19; A randomized clinical trial in the Covid-19 uninfected people with vitamin D deficiency.
No data are available on the effect of Weekly 50,000 IU vitamin D3 supplements on the serum
levels of selected cytokines involved in cytokine storm of Covid-19 in the Covid-19
uninfected Jordanian people with vitamin D deficiency. This study was designed to investigate
whether a high dose of vitamin D3 (50,000 IU) / week for 8 weeks supplementation has a
potential effect on cytokine storm of Covid-19; such as IL-1 beta, IL-6, and TNF in the
Covid-19 uninfected Jordanian people with vitamin D deficiency.
This study aims to assess whether high doses of vitamin D3 may improve immune responses
against COVID-19 infection in uninfected Jordanian peoples. We hypothesize that Weekly 50,000
IU vitamin D3 supplements will significantly change immune responses compared with the
control group.
Dietary Supplement: Vitamin D3
Dietary Supplement: Vitamin D3 (50,000) IU / week for 8 weeks
Other Name: cholecalciferol
Inclusion Criteria:
Age ≥30 years old Male and female Jordanian ASU students and employees who live in Amman.
Informed written consent from the participant prior to the start of the study. a serum
25(OH)D concentration less than 30 ng/mL.
Exclusion Criteria:
Any eligible subject refuses to apply with informed written consent before the start of the
study. Men or women previously diagnosed with chronic diseases, including kidney disease or
GIT problems. Who are receiving vitamin D3 supplements (3 months before the start of the
study). Pregnant, Breastfeeding females, Females using hormonal contraceptives
Mahmoud S Abu-Samak
Amman, Jordan