Official Title
EEG-based Protocol to Guide Deep Sedation Decreases the Days of Mechanical Ventilation in Patients With SARS-CoV-2 Pneumonia: Randomized Clinical Trial
Brief Summary

Deep sedation in patients with COVID-19 may be challenging in many aspects. The use of an EEG-based protocol to guide deep sedation may be useful in this particular population, considering their unusually high sedation requirements. In the present trial, we aim to evaluate an EEG-based protocol to guide deep sedation in patients with COVID19, using to EEG derived parameters that are displayed in the BIS monitor: Suppression Rate and Spectral Edge Frequency. The protocol is designed to both minimize the suppression rate along with maintaining a spectral edge frequency over 10 Hz. The use of this protocol may reduce the amount of sedatives administered and, therefore, diminish the time needed for the weaning process.

Completed
Sedation Complication
COVID19

Other: EEG based protocol for deep sedation

Protocol established to guide sedation drug dosification to maintain the patient with a Suppression Rate (SR) less than 1% and a Spectral Edge Frequency 95 over 10 Hz

Eligibility Criteria

Inclusion Criteria:

- Patients over 18 years old

- COVID-19 patient requiring mechanical ventilation

Exclusion Criteria:

- Contraindication to receive propofol or fentanyl

- Chronic Liver Disease Child C

- End-Stage Kidney Chronic Disease

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Chile
Locations

Hospital Clinico de la Universidad de Chile
Santiago, RM, Chile

University of Chile
NCT Number
MeSH Terms
Pneumonia