This research study will evaluate the association of Androgen Receptor (AR) gene expression and COVID-19 disease severity and mortality. The research procedure involves collection of a single saliva sample which will be mailed to the participants by the study team. This saliva will be used in a COVID-19 Androgen Sensitivity Test (CoVAST) which will detect AR gene expression. Eligible participants are males, at least 18 years or older, and have tested positive for COVID-19.
Genetic: COVID-19 Androgen Sensitivity Test (CoVAST)
The CoVAST Test is an in-vitro non diagnostic test. The test reports the genetic health risk of male patients in developing severe symptoms following COVID 19 infection. The genetic information provided by this test will help physicians evaluate the association of AR gene polymorphism with disease severity and mortality following COVID-19 infection. The CoVAST Test is indicated for reporting of the following variant associated with the following gene.
Inclusion Criteria:
- Male over the age of 18
- Laboratory confirmed SARS-CoV-2 infection
- Able to give verbal informed consent
Exclusion Criteria:
- Unable to give informed consent
- Diagnosed with an additional respiratory co-infection
- XXY males
Applied Biology, Inc
Irvine, California, United States
University of California, Irvine - Dermatology Clinical Research
Irvine, California, United States
Natasha Mesinkovska, MD, PhD, Principal Investigator
University of California, Irvine