COVID 19 Viral Clearance Among the Infected Healthcare Workers In Assiut University Hospitals

COVID-19 has been spreading rapidly globally, with a considerable impact on global morbidity,
mortality and healthcare utilization. This viral disease is caused by the Coronaviruses (CoV)
which belong to the genus'coronavirus' of the Coronaviridae family.

Coronaviruses are enveloped positive strand RNA viruses with the largest known RNA
genomes-30-32 kb-with a 50 -cap structure and 30 -poly-A tail (Lei et al.2018). The
transcription works through the replication-transcription complex (RCT) organized in
double-membrane vesicles and via the synthesis of subgenomic RNAs (sgRNAs) sequences. Of
note, transcription termination occurs at transcription regulatory sequences, located between
the so-called open reading frames (ORFs). In the atypical CoV genome, at least six ORF scan
could be present (Woo et al., 2020) .

Health workers are at the front line of the COVID-19 outbreak response and as such are
exposed to hazards that put them at risk of infection (Li e al.,2020). thus keeping the
implementation of infection prevention and control (IPC) and its knowledge and practice are
of great importance in healthcare settings to protect them from infections (Wang et al.,
2020).