Official Title
COVID-19 Primary Care Platform for Early Treatment and Recovery (COPPER) Study: an Open-label Randomized Controlled Trial
Brief Summary

The COVID-19 coronavirus has led to a global pandemic of respiratory diseases with an increase in hospitalization and death risk. To keep COVID-19 manageable for healthcare, early treatment is urgently needed to avoid hospitalization. Dexamethasone can dampen the exaggerated cytokine response to COVID-19 and is a promising agent for preventing disease aggravation, hospitalization and death. However, the evidence on the effectiveness, safety and cost-effectiveness of dexamethasone treatment in primary care is inconclusive.

Terminated
COVID19
Corona Virus Infection

Drug: Dexamethasone

6 mg dexamethasone prescribed during ten days and as a precaution combined with electronic monitoring of saturation and other signs and symptoms

Eligibility Criteria

Inclusion Criteria:

- Age ≥18 years

- A positive test for SARS-CoV-2

- A GP consultation for deteriorating COVID-19 symptoms

Additional inclusion criteria in order to be eligible for randomization to the trial:

- Exercise-induced desaturation, defined as SpO2<92% (<90% for COPD patients) and/or an
absolute drop of ≥4% in SpO2 after a 1-minute sit-to-stand test

OR

- SpO2<92% (<90% for COPD patients) in rest with GP's and patient's shared decision to keep
patient at home despite this in itself being an indication for referral to hospital

Exclusion Criteria:

- Inability to understand and sign the written consent form

- Inability to perform saturation measurements or sit-to-stand test

- Not willing to be admitted to hospital

- On the discretion of the recruiting clinician if he or she deems a patient not
eligible

The following criterion will be used to exclude patients from randomization to the trial:

- Contra-indication for dexamethasone

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Netherlands
Locations

GPRI
Groningen, Netherlands

Janwillem Kocks, Prof, Principal Investigator
General Practitioners Research Institute

Huisartsenzorg Drenthe
NCT Number
MeSH Terms
COVID-19
Coronavirus Infections
Dexamethasone