This is a prospective cohort study of pregnant patients at an urban academic center diagnosed with perinatal COVID-19 infection, followed up to 6 weeks postpartum.
This proposal aims to provide a multi-faceted approach to addressing perinatal COVID-19
infection by (1) improving our understanding of SARS-CoV-2 antibody specificity and
durability over the course of pregnancy/postpartum in mother/baby dyad (2) understanding the
downstream implications of maternal systemic inflammatory response with COVID-19 infection
through study of fetal inflammatory response, placental pathology, and perinatal outcomes,
and (3) to evaluate the interplay between socioeconomic characteristics, COVID-19, and early
neonatal outcomes. (4) Evaluate antibody generation and durability in pregnant/breastfeeding
women who receive any form of the COVID-19 vaccine
Other: COVID-19 exposure
COVID-19 exposure during pregnancy
Biological: COVID-19 vaccine
Receipt of any COVID-19 vaccine
Inclusion Criteria:
- Diagnosis of COVID-19 in pregnancy or within 6 months post partum
- Planned delivery at Thomas Jefferson University Hospital
Exclusion Criteria:
- Declines routine COVID testing on admission
- In active labor/pain/otherwise unable to provide consent
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States