COVID-19 pandemic with SARS-CoV-2 infection has become a global challenge. Though most cases of COVID-19 are mild, the disease can also be fatal. Patients with liver cirrhosis are more susceptible to damage from SARS-CoV-2 infection considering their immunocompromised status. The spectrum of disease and factors that influence the disease course in COVID-19 cases with liver cirrhosis are incompletely defined. This muilticentre observational study (COVID-Cirrhosis-CHESS2002) aims to study the clinical characteristics and risk factors associated with specific outcomes in COVID-19 patients with pre-existing liver cirrhosis.
Coronavirus disease 2019 (COVID-19) pandemic with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection has become a global challenge. Though most cases of
COVID-19 are mild, the disease can also be fatal. Patients with liver cirrhosis are more
susceptible to damage from SARS-CoV-2 infection considering their immunocompromised status.
The spectrum of disease and factors that influence the disease course in COVID-19 cases with
liver cirrhosis are incompletely defined. This muilticentre observational study
(COVID-Cirrhosis-CHESS2002) aims to study the clinical characteristics and risk factors
associated with specific outcomes in COVID-19 patients with pre-existing liver cirrhosis.
Inclusion Criteria:
- 1) Aged 18 or above;
- 2) Laboratory-confirmed COVID-19 infection;
- 3) Pre-existing liver cirrhosis based on liver biopsy or clinical findings.
Exclusion Criteria:
- 1) Pregnancy or unknown pregnancy status.
Dalian Sixth People's Hospital
Dalian, China
Minda Hospital Affiliated to Hubei University for Nationalities
Enshi, China
The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture
Enshi, China
The First Hospital of Lanzhou University
Lanzhou, China
The Central Hospital of Lishui City
Lishui, China
Guangxi Zhuang Autonomous Region
Nanning, China
The Sixth Peoples Hospital of Shenyang
Shenyang, China
Shenzhen Third People's Hospital
Shenzhen, China
Suizhou Hospital, Hubei University of Medicine
Suizhou, China
Tianjin Second People's Hospital
Tianjin, China
Ankang Central Hospital
Wuhan, China
Renmin Hospital of Wuhan University
Wuhan, China
Wuhan Union Hospital
Wuhan, China
Xingtai People's Hospital
Xingtai, China
The Affiliated Third Hospital of Jiangsu University
Zhenjiang, China