COVID-19 and Rare Skin Diseases European Observational Study During an Epidemic

Medical and demographic data will be collected from the medical records of patients. The data
required will be specified in Appendix 1 (collection form). Patients will be identified by
their initials (first letter of their surname and first name); The study will last for one
year to cover the COVID-19 epidemic in France (which includes the areas of mainland France
and its overseas departments and territories) and in Europe, via the ERN-Skin European
Network.

The frequency of severe forms of COVID-19 will be calculated with a bilateral 95% confidence
interval using, as a numerator, the number of patients with a severe form of COVID-19 and, as
a denominator, the number of patients with a COVID-19 diagnosis confirmed by PCR, chest scan,
serological assay or by suggestive clinical signs during the medical consultation. A severe
form of COVID is defined as a case requiring hospitalisation in an intensive care unit,
requiring resuscitation, or resulting in death.

Analysis of the impact of COVID-19 infection on rare skin diseases: complications, potential
comorbidity factors, impact on the management of chronic conditions (change in treatment) and
the experience of patients.

The results of the analysis may be compared with those obtained for other groups of diseases.
Gaining a better understanding of high-risk situations, as well as any aggravation or
protective factors, should enable us to issue recommendations adapted to this kind of disease
but that may also be useful for the general population. This type of study may also provide
"reassurance" to patients with rare diseases who have many questions during this period of
epidemic and heightened concern.