Official Title
Correlation Between Oxidative Stress Markers and COVID-19 Severity Index
Brief Summary

During the new COVID-19 pandemic physicians all over the world have faced different challenges .Oxidative stress is a probable cause of multi organ failure in this setting which never has been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate oxidative stress marker and redox system status in different COVID-19 patients regarding the severity of involvement.

Detailed Description

Oxidative stress is a probable cause of multi organ failure in this setting which never has
been evaluated in COVID-19 infection to the best of knowledge.Present study aimed to evaluate
oxidative stress marker and redox system status in different COVID-19 patients regarding the
severity of involvement. Demographic and lab data of 60 COVID-19 confirmed positive cases
gathered .These patients divided in to two arms: 1- severe COVID-19 which were intubated or
admitted in intensive care unit due to severe hypoxia 2- non-severe COVID-19 patients which
were not hypoxic and admitted in ward with no need to invasive oxygenation. All patients had
positive RT-PCR positive nasopharyngeal swab results for COVID-19 or Lung CT scan compatible
with COVID-19. Malondialdehyde(MDA) , Biopterin, Neopterin, SOD, Glutathione levels would be
checked by ELISA tests and compared between these two groups and healthy controls.

Unknown status
Oxidative Stress

Diagnostic Test: Oxidative Stress ELISA Kit

Checking oxidative stress markers and redox system status

Eligibility Criteria

Inclusion Criteria:

- more than 18 years old

- positive RT-PCR COVID-19

- compatible lung CT with COVID-19

Exclusion Criteria:

- not signing informed consent

- using antioxidants

- using statins

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Iran, Islamic Republic of
Locations

Nooshin Dalili
Tehran, Iran, Islamic Republic of

Investigator: Nooshin Dalili, Dr
Contact: 00989122404331
nooshindalili4@gmail.com

Contacts

Nooshin Dalili
00989122404331
nooshindalili4@gmail.com

Dalili, Principal Investigator
SBMU

Shahid Beheshti University of Medical Sciences
NCT Number