CORIA is an observational cohort study of immunosuppressed populations who test positive for COVID-19. This includes people living with HIV, cancer, acquired immunodeficiency associated with other immunosuppressive therapy, primary immunodeficiency and recipients of a solid organ transplant. Participants will have routine clinical data collected with optional baseline collection and storage of a blood sample for storage . The study will be conducted in up to 30 sites within Australia.
Inclusion Criteria:
1. Presenting (in person or via telemedicine) for evaluation because they:
- Have clinical symptoms consistent with for COVID-19:
- Fever (≥ 37.8 °C) on examination OR patient reported fever (≥ 37.8 °C) or
feverishness (felt febrile but did not take temperature) OR any of, cough, sore
throat, shortness of breath, rhinorrhoea, headache, chills, generalise myalgia,
malaise, fatigue, confusion, diarrhea, nausea or vomiting
- Have been contacted because they have been identified as a contact to a confirmed
case
- Have been contacted and told they tested positive for COVID-19
2. Have one of the following conditions affecting immune function:
- Known or suspected primary immunodeficiency, defined as a predisposition to
infection associated with an apparent or presumed deficit of immune function
- On immunosuppressive therapy
- Treatment with immune checkpoint inhibitors within 36 months of enrolment date
- HIV infection
- Diagnosis of cancer within 36 months of enrolment date, excluding superficial
basal cell and squamous cell carcinomas
- Solid organ transplantation
3. For optional biobanking only, ability to provide informed consent
Exclusion Criteria:
- Nil
St Vincent's Hospital
Darlinghurst, New South Wales, Australia
East Sydney Doctors
Sydney, New South Wales, Australia
Royal North Shore Hospital
Sydney, New South Wales, Australia
Blacktown Hospital
Sydney, New South Wales, Australia
Liverpool Hospital
Sydney, New South Wales, Australia
St George Hospital
Sydney, New South Wales, Australia
Concord Hospital
Sydney, New South Wales, Australia
Holdsworth House Medical Practice
Sydney, New South Wales, Australia
Melanoma Institute Australia
Sydney, New South Wales, Australia
Nepean Hospital
Sydney, New South Wales, Australia
Westmead Hospital
Sydney, New South Wales, Australia
Mark Polizzotto, MD, Principal Investigator
Kirby Institute, UNSW