Convalescent Plasma for Treating Patients With COVID-19 Pneumonia Without Indication of Ventilatory Support

Recipient Inclusion Criteria:

- Confirmed diagnosis of COVID-19 by RT-PCR;

- Time between symptom onset and inclusion ≤ 7 days;

- Chest tomography with <50% involvement of the lung parenchyma;

- No indication of ventilatory support at the time of randomization;

- Sign the consent form.

Recipient Exclusion Criteria:

- Contraindication to transfusion or history of previous reactions to blood products for
transfusion;

- Pregnant women;

- Limiting comorbidity for administering the therapies provided for in this protocol in
the opinion of the investigator.

Donor Inclusion Criteria for Plasmapheresis:

- Convalescent plasma donation will be eligible for patients ≥ 18 years old who had
previously confirmed COVID-19 by RT-PCR, which met the criteria adopted by technical
notes n13 and 21/2020-CGSH/DAET/SAES/MS;

- SARS-COV-2 negative RT-PCR;

- Asymptomatic for at least 14 days;

- SARS-CoV-2 anti-peak titre with dilution ≥ 1: 320;

- Sign the consent form.

Donor Exclusion Criteria:

- Female gender with previous pregnancy;

- Absence of peripheral venous network compatible with the apheresis procedure;

- Positive or indeterminate result in any of the infectious screening tests;

- Presence of intellectual incapacity to understand the guidelines regarding the risks
and benefits of participating in the study.