This is a double-blinded, randomized control trial to assess the efficacy and safety of anti-SARS-CoV-2 convalescent plasma as early treatment. Participants will be randomized 2:1 to receive either convalescent plasma qualitatively positive for SARS-CoV-2 antibody ("anti-SARS-CoV-2 plasma") or control (albumin 5%). This study will investigate the potential of convalescent plasma (CP) to reduce severity of and/or help treat SARS-CoV-2 disease in patients with mild disease.
There are no approved therapies for Coronavirus disease 2019 (COVID-19), also known as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Exposure to viruses results in an
adaptive immune response that commonly include antibodies with neutralization activity.
Plasma from subjects who have recovered from viral infections has been used to both prevent
or treat disease. Notable examples of the successful use of convalescent plasma (CP) include
influenza, measles, Argentine hemorrhagic fever, Middle East respiratory syndrome (MERS),
Ebola and severe acute respiratory syndrome (SARS). In recent work in China, an open label
safety trial of CP in patients with COVID-19 suggested a substantive benefit.
Biological: Convalescent Plasma (anti-SARS-CoV-2 plasma)
Convalescent Plasma that contains antibody titers against SARS-CoV-2.
Biological: Control (albumin 5%)
Albumin (Human) 5% is a sterile aqueous solution for intravenous use containing the albumin component human plasma.
Inclusion Criteria:
- Subjects must be 18 years of age or older
- Recent close contact with a person with COVID-19, i.e. last close contact occurred
within 7 days of anticipated infusion of study product. It is anticipated that most
contacts will be household contacts with extensive interaction. All must meet the CDC
criteria for close contacts. This includes healthcare workers at higher risk of
developing severe disease.
OR
- Recent self-reported or documented evidence of infection by nasal swab PCR that is
positive for SARS-CoV-2, i.e., nasal sample was collected within 7 days or 10 days of
anticipated infusion of study product for those who are asymptomatic or symptomatic,
respectively.
- Evidence of infection by nasal swab PCR that is positive for SARS-CoV-2 at screening
visit.
- May or may not be hospitalized.
- No symptoms or no more than 5 days of mild symptoms at the time of screening. Mild
symptoms (rated by participant as mild and not interfering with normal daily
activities) may include:
- Mild rhinorrhea
- Mild sore throat or throat irritation
- Mild nonproductive cough
- Mild fatigue (able to perform Activities of Daily Living (ADLs))
- Risk for severe COVID-19 based on a risk score of ≥ 1 Calculated Risk Score of ≥ 1
point, with risk factors based on Center for Disease Control and Prevention (CDC)
description
- Age 65-74: 1 point
- Age ≥ 75: 2 points
- Known cardiovascular disease (including hypertension): 1 point
- Diabetes mellitus: 1 point
- Pulmonary disease (COPD, moderate to severe asthma, current smoking or other): 1
point
- Morbid obesity: 1 point
- Immunocompromised state: 1 point Received a bone marrow or solid organ transplant
at any time, received chemotherapy for a malignancy within the past 6 months, has
an acquired or congenital immunodeficiency, currently receiving immunosuppressive
or immune modulating medications, HIV with non-suppressed viral load and/or
cluster of differentiation 4 (CD4+) T cell count <200 cells/mL).
Exclusion Criteria:
- Receipt of any blood product in past 120 days.
- Psychiatric or cognitive illness or recreational drug/alcohol use that in the opinion
of the principal investigator, would affect subject safety and/or compliance.
- Confirmed or self-reported presumed COVID-19, with symptoms that began more than 5
days prior to enrollment, and SARS-CoV-2 PCR positive sample that was collected more
than 7 days prior to anticipated infusion for an asymptomatic participant or more than
10 days prior to anticipated infusion for a patient with mild symptoms at screening.
- Symptoms consistent with COVID---19 infection that are more than mild (as defined
above) at time of screening.
- Symptoms consistent with COVID---19 infection that are more than mild at time of
screening.
- History of allergic reaction to transfusion blood products
- Inability to complete infusion of the product within 48 hours after randomization.
- Resident of a long term or skilled nursing facility
- Known prior diagnosis of immunoglobulin A (IgA) deficiency
- Oxygen saturation that is < 95% at the screening visit
- On supplemental oxygen at time of enrollment
- Participation in another clinical trial of anti-viral agent(s) for COVID-19
- Receipt of any COVID-19 vaccine, either as part of a clinical research trial or
through routine service delivery.
National Institute of Infectious Diseases Evandro Chagas (INI)
Rio de Janeiro, Brazil
Jessica Justman, MD, Principal Investigator
Columbia University