Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.
Device: Extravascular Lung Water Index
Measurement of the EVLWI
Device: Pulmonary Vascular Permeability Index
Measurement of the PVPI
Inclusion Criteria:
- ARDS defined by Berlin Criteria longer than 24 hours
- Undergoing mechanical ventilation
- Noradrenaline demand >0.1 mcg/kg/min
Exclusion Criteria:
- Not meeting ARDS criteria
- Noninvasive mechanical ventilation
- ARDS resolved shorter than 24 hours
- Shock resolved
Istanbul University-Cerrahpaşa
Istanbul, Turkey
Yalım Dikmen, Prof, Study Director
Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine