Cytokines and chemokines are thought to play an important role in immunity and immunopathology during virus infections [3]. Patients with severe COVID-19 have higher serum levels of pro-inflammatory cytokines (TNF-α, IL-1 and IL-6) and chemokines (IL-8) compared to individuals with mild disease or healthy controls, similar to patients with SARS or MERS . The change of laboratory parameters, including elevated serum cytokine, chemokine levels, and increased NLR in infected patients are correlated with the severity of the disease and adverse outcome, suggesting a possible role for hyper-inflammatory responses in COVID-19 pathogenesis. Importantly, previous studies showed that viroporin E, a component of SARS-associated coronavirus (SARS-CoV), forms Ca2C-permeable ion channels and activates the NLRP3 inflammasome. In addition, another viroporin 3a was found to induce NLRP3 inflammasome activation . The mechanisms are unclear. Colchicine, an old drug used in auto-inflammatory disorders (i.e., Familiar Mediterranean Fever and Bechet disease) and in gout, counteracts the assembly of the NLRP3 inflammasome, thereby reducing the release of IL-1b and an array of other interleukins, including IL-6, that are formed in response to danger signals. Recently, colchicine has been successfully used in two cases of life-threatening post-transplant capillary leak syndrome. These patients had required mechanically ventilation for weeks and hemodialysis, before receiving colchicine, which abruptly restored normal respiratory function and diuresis over 48 hrs [4].
Drug: Colchicine
Cochicine 1mg/day
Inclusion Criteria:
- Positive nasopharyngeal swab for COVID-19, asymptomatic or paucisymptomatic, aged ≥70
years and/or with clinical risk factors for poor outcome (clinically relevant chronic
lung disease, diabetes and/or heart disease) or
- symptomatic with respiratory or systemic symptoms, however clinically stable (MEWS<3)
with CT imaging showing viral pneumonia and positive or pending pharyngo-nasal swab
for COVID-19: Temperature 38°C and/or intensive cough, Respiratory rate < 25 /min,
oxygen saturation (pulse oximetry) >95%
- Positive swab for COVID-19
- with respiratory and/or systemic symptoms and initial mild respiratory failure e with
objective signs of lung involvement; the patient is in stable conditions (MEWS < 3)
Temperature>38°C and or intensive cough, Respiratory rate ≥25 /min, or oxygen
saturation 94- 95% in room air
Exclusion Criteria:
- Pregnant or breast feeding
- MEWS >=3
- Hepatic failure Child-Pugh C
- Enrollment in other pharmacological studies
- Ongoing treatment with colchicine
- Ongoing treatment with antiviral drugs that include ritonavir or cobicistat
- Any medical condition or disease which in the opinion of the Investigator may place
the patient at unacceptable risk for study participation.
Azienda Ospedaliero Universitaria di Parma
Parma, PR, Italy
Umberto Maggiore, MD, Principal Investigator
Azienda Ospedaliero-Universitaria di Parma