A Clinical Study to Assess the Physiologic Effects of KB109 in Patients With COVID-19 on Gut Microbiota Structure and Function

To be considered for enrollment into this study, each patient must meet all of the
following Inclusion Criteria:

1. Be male or female, ≥18 years of age

2. Be willing and able to give informed consent

3. Screening/Randomization telemedicine visit within 2 days of testing positive test for
COVID-19

4. Having self-reported fever or cough for not more than 72 hours prior to COVID-19
testing

5. Mild to moderate COVID-19

6. Able to adhere to the study visit schedule and other protocol requirements

Patients who meet any of the following Exclusion Criteria at the Randomization Visit will
not be enrolled into the study:

1. Patients who are hospitalized for in-patient treatment or currently being evaluated
for potential hospitalization at the time of informed consent for conditions other
than COVID-19

2. History of chronic lung disease

3. Ongoing requirement for oxygen therapy

4. Shortness of breath in resting position

5. Diagnosis of sleep apnea requiring Bilevel Positive Airway Pressure (BIPAP) /
Continuous Positive Airway Pressure (CPAP)

6. Female patients who are pregnant, trying to become pregnant or lactating.

7. Is considered, in the opinion of the PI, to be unlikely for any reason to be able to
comply with study procedures