The main objective of this retrospective clinical epidemiology study is to describe the characteristics of Covid-19 cases requiring hospitalization in adult patients with lymphomas during the initial phase of the epidemic (from 01/03/20 to 30/04/20). The specific objectives are to estimate the frequency of severe forms of Covid-19 and those requiring intensive care hospitalisation, as well as the mortality related to the epidemic among the active file of patients followed for lymphoma at each study site, to investigate whether certain chemotherapy and/or immunotherapy treatments seem to be associated with severe forms or prolonged evolutions of Covid-19, to describe possible atypical clinical forms among the population of patients treated for lymphoma. Translated with www.DeepL.com/Translator (free version)
I
Methods :
- Multicentric retrospective observational epidemiological study based on the collection
of data from patient records.
- Selection of voluntary hospital sites in regions with excess mortality during the
epidemic phase.
- Systematic identification of Covid-19 cases from coding data (PMSI) from the medical
information departments which will be compared with the numbers of patients followed for
lymphoma in the haematology departments of each site during the 6 months preceding the
epidemic, identified through the PMSI.
- Establishment of an ad hoc CRF for cases only with collection of clinical data
concerning lymphoma and Covid-19 and routine biological data: Cytopenia (and in
particular depth of lymphopenia), hypogammaglobulinemia, inflammatory markers.
- Estimated total number of sites: 10-15 and number of cases to be collected: 50-60.
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Inclusion Criteria:
- Patients at least 18 years of age with lymphoma and a diagnosis of Covid-19 requiring
hospitalization.
- In order not to bias the data by excluding patients with adverse outcomes, we will
also collect data from deceased patients.
Exclusion Criteria:
Patients who refused to participate
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CH de Versailles
Le Chesnay, France