This is a multi-center prospective study that aims to investigate the clinical and immunologic impact of SARS-CoV-2 infection in pregnant women and neonates. The goal is to recruit 200 SARS-CoV-2 infected pregnant women starting at 24 weeks of gestation in a neonatal network of 45.000 birth a year. Clinical data will be collected from women and neonates. Upper airways samples will be obtained from both for bio-markers investigation. Finally, maternal and umbilical cord serum and human milk will be obtained for antibody assessment.
COVID-19, the disease caused by the novel coronavirus SARS-CoV-2, has led to an unprecedented
global pandemic affecting persons of all ages. Pregnant women are in a physiologic
immunosuppressed situation and have a greater risk and severity of respiratory infection.
However, considerable uncertainty exists regarding the potential for vertical transmission
(prenatal/congenital or perinatal) of SARS-CoV-2 from infected pregnant women to their
newborns and its potential clinical consequences.
This study attempts to provide evidence-based guidelines for managing antenatal, intrapartum,
and neonatal care around COVID-19 require an understanding of whether the virus can be
transmitted transplacentally; a determination of which maternal body fluids may be
infectious; trasnplacental and human milk antibody transfer and data of adequate statistical
power that describe which maternal, intrapartum, and neonatal factors influence perinatal
transmission.
Inclusion Criteria:
- Pregnant women hospitalized presenting with:
1. Fever with one or more respiratory symptoms (cough, odinophagia, respiratory
difficulty)
2. Diagnoses of pneumonia with no other explainable cause.
Exclusion Criteria:
- None
Hospital Italiano
Buenos Aires, Argentina