A population-based COVID19 surveillance in a household cohort will be set-up using an existing Household demographic surveillance system (HDSS). From any individual in this population with any respiratory symptom or loss of smell or taste, with or without fever, investigators will collect a respiratory specimen and test these for SARS-CoV-2 virus, during 12 months. Demographic, epidemiological and clinical data of possible cases and of the source population will be recorded at baseline. An age-stratified serial sero-survey will be conducted at baseline in a subset of the population in the population-based COVID19 surveillance, and at 3, 6 and 12 months, after confirmation of community transmission.
The investigators will use the established HDSS to set up population-based COVID19
surveillance in a household cohort. From any individual in this population with any
respiratory symptom or loss of smell or taste, with or without fever, investigators will
collect a respiratory specimen and test these for SARS-CoV-2 virus by PCR, during 12 months.
These cases will be identified through bi-weekly household visits, through an alert system
involving community leaders and HDSS interviewers, or when presenting with symptoms at
healthcare centres or the referral hospital. Demographic, epidemiological and clinical data
(comorbidities, medication, obesity, HIV, TB, smoking) of possible cases and of the source
population will be recorded at baseline; recent illness, potential risk exposure of each
household member (including duration and type) to SARS-CoV-2 positive individuals, uptake of
measures to reduce exposure/transmission, and barriers to the uptake of such measures, will
be recorded/updated during every household visit.
An age-stratified serial sero-survey will be conducted at baseline in a subset of the
population in the population-based COVID19 surveillance, and at 3, 6 and 12 months, after
confirmation of community transmission.
Inclusion Criteria:
- Any individual enrolled in the Polana Caniço-HDSS: All members residing in the
household for at least 3 months (infants, children, adults, elderly), regardless of
age, underlying conditions, medical history, infection or disease status or history
- Able and willing to provide written informed consent: by the household head for the
surveillance; by each selected participant for the sero-survey.
No Exclusion Criteria
INS
Maputo, Mozambique
Marc-Alain Widdowson, Dr, Principal Investigator
Institute of Tropical Medicine