Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the novel coronavirus disease 2019 (COVID-19) pandemic. Among COVID-19 complications, in-hospital cardiac arrest (IHCA) was reported with a very poor outcome in a retrospective single-center study (0,7% of 30 days survival with good neurological outcome among IHCA patients with a resuscitation attempt), related to its natural course and management. The incidence of unexpected in-ICU cardiac arrest (ICUCA) due to COVID-19 is still unknown. Additionally, outcome of COVID-19 patients admitted in ICU for an out-of-hospital cardiac arrest (OHCA) is also undescribed. The objective this study is : - to report the incidence of ICUCA among patients hospitalized in French ICU for COVID-19. - to report morbidity and mortality among COVID-19 patients admitted alive in ICU for an OHCA or an IHCA. The secondary objective is to assess outcome and identify risk factors of ICUCA occurrence among patients admitted for COVID-19.
Retrospective and prospective multicentric observational registry in French intensive care
units (ICU) including all consecutive adult patients admitted in ICU with a documented
SARS-CoV-2 disease :
- For an out-of-hospital or an in-hospital cardiac arrest (OHCA and IHCA respectively)
- Or presenting an unexpected in-ICU cardiac arrest (ICUCA) Patients characteristics,
cardiac arrest history and patients outcome will be recorded according to Utstein
recommendations.
Patients presenting an expected cardiac arrest in ICU related to withdrawal of life
sustaining therapies (WLST) will be excluded.
Other: Cardiopulmonary resuscitation
Cardiopulmonary resuscitation
Other: Modified Rankin score
0 - no symptoms at all
- no significant disability despite symptoms; able to carry out all usual duties and activities
- Slight disability; unable to carry out all previous activities, but able to look after own affairs without assistance
- Moderate disability; requiring some help, but able to walk without assistance
- Moderately severe disability; unable to walk and attend to bodily needs without assistance
- Severe disability; bedridden, incontinent and requiring constant nursing care and attention
- Dead
Inclusion Criteria:
- Patients admitted in intensive care unit with a documented SARS-CoV-2 disease
- For an out-of-hospital or an in-hospital cardiac arrest
- Or an in-hospital cardiac arrest
- Or presenting an unexpected in-intensive care unit cardiac arrest
Exclusion Criteria:
- Age under 18 y.o
- Expected in-intensive care unit cardiac arrest related to withdrawal of life
sustaining therapies.
- Withdrawal of patient or next-of-kin informed consent
CHU Caen
Caen, Calvados, France
Hôpital Privé St Martin
Caen, Calvados, France
CH Angoulème
Angoulême, Charente, France
CH Brive
Brive-la-Gaillarde, Corrèze, France
CHU Dijon
Dijon, Côte-d'Or, France
CH Etampes
Étampes, Essonne, France
CHU Antoine Béclère AP-HP
Clamart, Haut-de-Seine, France
CHU Ambroise Paré AP-HP
Boulogne-Billancourt, Hauts-de-Seine, France
CH Louis Mourier AP-HP
Colombes, Hauts-de-Seine, France
CHU Montpellier
Montpellier, Hérault, France
CHU Lariboisière AP-HP
Paris, Ile-de-France, France
CHU Saint Louis AP-HP
Paris, Ile-de-France, France
CHU St Antoine
Paris, Ile-de-France, France
Groupe Hospitalier Saint Joseph
Paris, Ile-de-France, France
CHU Necker Enfants Malades
Paris, Ile-de-France, France
CHU Pitié Salpétrière
Paris, Ile-de-France, France
CHU Felix Guyon
Saint-Denis, La Reunion, France
CHR Orléans
Orléans, Loiret, France
CH Cahors
Cahors, Lot, France
CHRU Roger Salengro
Lille, Nord, France
CH Bethune
Beuvry, Pas-de-Calais, France
CH Lens
Lens, Pas-de-Calais, France
Grand Hôpital de l'Est Francilien
Jossigny, Seine-et-Marne, France
CHU Meaux
Meaux, Seine-et-Marne, France
Groupe Hospitalier Sud Ile de France
Melun, Seine-et-Marne, France
CHU Rouen
Rouen, Seine-Maritime, France
CHU Amiens Picardie
Amiens, Somme, France
Hôpital Nord Franche Comté
Trévenans, Territoire De Belfort, France
CH Argenteuil
Argenteuil, Val-d'Oise, France
CHU Henri Mondor AP-HP
Créteil, Val-de-Marne, France
CHU Kremlin Bicêtre
Le Kremlin-Bicêtre, Val-de-Marne, France
CH de la Dracénie
Draguignan, Var, France
CHI Frejus St Raphael
Fréjus, Var, France
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
Toulon, Var, France
CH Versailles
Le Chesnay, Yvelines, France
CHU Martinique - Fort de France
Fort-de-France, Martinique
Jonathan Chelly, MD, Study Director
Centre Hospitalier Intercommunal Toulon La Seyne sur Mer