Official Title
Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) - Population-based Registry of Suspected and Confirmed COVID-19 Cases
Brief Summary

Coronavirus Disease 2019 (COVID -19) is the largest public health crisis in over a century. There is an urgent need for high-quality population-level data to understand modifiable risks for disease severity, transmissibility, and to develop evidence-based prevention (i.e. vaccination), treatment and resource allocation strategies. The Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) created a population-based registry of suspected and confirmed consecutive cases of COVID-19. The purpose of this registry is to derive and validate clinical decision rules, evaluate diagnostic tests and vaccine effectiveness, and complete cohort, case-control and observational studies to inform the pandemic response.

Detailed Description

This national multi-centre registry is designed to enroll population-based consecutive
eligible patients presenting with suspected or confirmed COVID-19 to 50 emergency departments
in eight Canadian provinces from March 1 2020 and data collection is ongoing for the duration
of the pandemic.

Data will be abstracted from the medical chart and entered into a central, web-based REDCap
database. The investigators adopted the ISARIC variables into the database where there was a
match. The investigators will develop standardized operating procedures for screening of
potentially eligible patients, data entry and follow-up. Current data dictionaries are kept
on the registry's website (https://canadiancovid19registry.org/).

At 30 days, the investigators will contact patients by telephone to obtain verbal consent for
follow-up. The investigators will measure the Veterans Rand 12-item Health Survey (VR12),
calculate the WHO Ordinal Outcome Scale and ask contextual questions in consenting patients.
The VR12 will be measured at 60 days, and 6 and 12 months. The contextual questions were
developed with input from patients with lived experience with COVID-19 infection and
addressed cultural, racial, gender, socioeconomic and self-isolation issues.

The Health Data Research Network facilitated the development of a unique data flow of
personal health identifiers and study identification numbers from each province for all
participating institutes. This will allow linkage of registry data with national
administrative data repositories.

Recruiting
COVID-19
Eligibility Criteria

The investigators defined two periods for enrollment based on the availability of COVID-19
testing. Research assistants used medical microbiology testing and discharge diagnoses to
screen for potentially eligible patients.

In Period 1, COVID-19 testing in each province was restricted to specific patient
populations (e.g., healthcare workers, admitted patients).

Inclusion Criteria:

- Meeting the WHO suspect COVID-19 criteria: Fever (self-reported or subjective fever)
and at least one symptom/sign of respiratory illness (e.g., flu-like illness, cough,
shortness of breath)

- Presenting to the emergency department and tested for COVID-19 in the emergency
department

No exclusion criteria in Period 1

Period 2 started on the date which each province expanded testing criteria allowing
clinicians to test patients based on clinical suspicion or policy.

Inclusion Criteria:

- Presenting to the emergency department within 14 days of a positive COVID-19 (by
self-report or in medical chart) and presents with clinical symptoms consistent with
COVID-19

- Tested for COVID-19 in the emergency department, or within 24 hours after emergency
department arrival.

Exclusion Criteria

- Patients tested for COVID-19 in the context of an elective admission (e.g., planned
hip revision)

- Patients tested for COVID-19 and seen in the emergency department directly by another
service (e.g., trauma team activation)

Eligibility Gender
All
Eligibility Age
Minimum: N/A ~ Maximum: N/A
Countries
Canada
Locations

Foothills Medical Centre
Calgary, Alberta, Canada

Peter Lougheed Centre
Calgary, Alberta, Canada

Rockyview General Hospital
Calgary, Alberta, Canada

South Health Campus
Calgary, Alberta, Canada

Northeast Community Health Centre
Edmonton, Alberta, Canada

Royal Alexandra Hospital
Edmonton, Alberta, Canada

University of Alberta Hospital
Edmonton, Alberta, Canada

Abbotsford Regional Hospital
Abbotsford, British Columbia, Canada

Royal Inland Hospital
Kamloops, British Columbia, Canada

Kelowna General Hospital
Kelowna, British Columbia, Canada

Royal Columbian Hospital
New Westminster, British Columbia, Canada

Lions Gate Hospital
North Vancouver, British Columbia, Canada

Eagle Ridge Hospital
Port Moody, British Columbia, Canada

Surrey Memorial Hospital
Surrey, British Columbia, Canada

Mount Saint Joseph Hospital
Vancouver, British Columbia, Canada

St. Paul's Hospital
Vancouver, British Columbia, Canada

Vancouver General Hospital
Vancouver, British Columbia, Canada

Saint John Regional Hospital
Saint John, New Brunswick, Canada

Dartmouth General Hospital
Dartmouth, Nova Scotia, Canada

Halifax Infirmary
Halifax, Nova Scotia, Canada

Cobequid Community Health Centre
Lower Sackville, Nova Scotia, Canada

Hants Community Hospital
Windsor, Nova Scotia, Canada

Hamilton General Hospital
Hamilton, Ontario, Canada

Juravinski Hospital
Hamilton, Ontario, Canada

Hotel Dieu Hospital
Kingston, Ontario, Canada

Kingston General Hospital
Kingston, Ontario, Canada

London Health Sciences Centre (University Hospital)
London, Ontario, Canada

London Health Sciences Centre (Victoria Hospital)
London, Ontario, Canada

The Ottawa Hospital - Civic Campus
Ottawa, Ontario, Canada

The Ottawa Hospital - General Campus
Ottawa, Ontario, Canada

Health Science North
Sudbury, Ontario, Canada

North York General Hospital
Toronto, Ontario, Canada

Sunnybrook Hospital
Toronto, Ontario, Canada

Toronto Western Hospital
Toronto, Ontario, Canada

Hôtel-Dieu de Lévis
Lévis, Quebec, Canada

Hôpital du Sacré-Coeur
Montréal, Quebec, Canada

Jewish General Hospital
Montréal, Quebec, Canada

Montréal General Hospital (MUHC)
Montréal, Quebec, Canada

Royal Victoria Hospital (MUHC)
Montréal, Quebec, Canada

Centre Hospitalier de l'Université Laval (CHU de Québec)
Québec, Quebec, Canada

Hôpital de l'Enfant-Jésus (CHU de Québec)
Québec, Quebec, Canada

Hôpital du Saint-Sacrement (CHU de Québec)
Québec, Quebec, Canada

Hôpital Saint-François d'Assise (CHU de Québec)
Québec, Quebec, Canada

Hôtel-Dieu de Québec (CHU de Québec)
Québec, Quebec, Canada

Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Quebec, Canada

Pasqua Hospital
Regina, Saskatchewan, Canada

Regina General Hospital
Regina, Saskatchewan, Canada

Royal University
Saskatoon, Saskatchewan, Canada

Saskatoon City Hospital
Saskatoon, Saskatchewan, Canada

St Paul's Hospital
Saskatoon, Saskatchewan, Canada

Contacts

Corinne M Hohl, MD, MSc
604-875-4111
corinne.hohl@ubc.ca

Laurie Morrison, MD,MSc
416-864-6060 - 7849
Laurie.Morrison@unityhealth.to

Corinne M Hohl, MD, MSc, Principal Investigator
University of British Columbia

University of British Columbia
NCT Number
Keywords
Coronavirus
infectious diseases
Registry
MeSH Terms
COVID-19
Emergencies