Novel coronavirus (SARS-CoV-2: severe acute respiratory coronavirus 2) pneumonia often develop the acute respiratory distress syndrome (ARDS). Lung protective ventilation strategy consisting of low tidal volume and high positive end-expiratory pressure (PEEP) is recommended. However, it is not clear whether injured lungs from SARS-CoV-2 pneumonia have the same mechanical properties, especially response to PEEP as common ARDS. Therefore, the investigators propose an observational study to analyze respiratory mechanics and lung recruitablity using EIT (electrical impedance tomography) in patients with ARDS due to SARS-CoV-2 pneumonia.
The multi-center prospective observational study will enroll 20 adult ARDS patients under
mechanical ventilation from Intensive Care Units (ICUs) in Japan and Peru. Informed consent
will be waived due to the nature of observational study. Patients with positive SARS-CoV-2
infection will be included. Prior to initiating the protocol, patients will be sedated deeply
with sedatives and/or opioids and paralyzed with a continuous infusion of rocuronium. The
distribution of ventilation will be evaluated with EIT.
Inclusion Criteria:
1. Patients with positive SARS-CoV-2 infection＊
2. Patients with ARDS under mechanical ventilation＊＊
3. Patients ≧ 18 years old
- Definition of SARS-CoV-2 infection positive: SARS-CoV-2 infection is defined as
being positive in RT-PCR (real time reverse transcriptase-polymerase chain
reaction) assay using nasal or pharyngeal swab samples.
- Definition of ARDS is as per the Berlin definition (PaO2/FiO2 ≦ 300 mmHg
with PEEP ≧ 5 cmH2O)
Exclusion Criteria:
1. Contraindication for EIT monitoring
1. Unstable spine or pelvic fractures
2. Pacemaker, automatic implantable cardioverter defibrillator
3. Skin lesions between the 4th and 5th ribs where the EIT belt is worn
2. Home mechanical ventilation before inclusion
3. Pregnancy
4. DNR (do-not-resuscitate)
5. Increased intracranial pressure (> 18 mmHg)
Osaka University Hospital
Suita, Osaka, Japan
Takeshi Yoshida, M.D., Ph.D., Principal Investigator
Osaka University