Official Title
Assessment of Lung Mechanics in SARS-CoV-2/ COVID-19 Acute Respiratory Distress Syndrome: A Holistic, Longitudinal Analysis of the Lung-heart-ventilator Interaction
Brief Summary

This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies. This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.

Unknown status
COVID19
ARDS

Diagnostic Test: Assessment of lung mechanics and heart-lung interactions

Impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry and classic mechanical ventilation parameters

Eligibility Criteria

Inclusion Criteria:

- SARS-CoV-2 infection

- Moderate to Severe ARDS after Berlin Classification at PEEP 5

- Admission to the Institute of Intensive Care of the University Hospital Zurich

- Invasive Mechanical Ventilation

- Signed Study Informed Consent or emergency procedure according to article 30 HFG

Exclusion Criteria:

- Pregnant or breast feeding patients

- Age <18 years

- Presumed rejection of the study intervention

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Switzerland
Locations

Institute of Intensive Care Medicine, University Hospital Zurich
Zurich, Switzerland

Investigator: Philipp K Buehler, MD
philipp.buehler@usz.ch

Contacts

Philipp K Buehler, MD
+41 43 25 31340
Philipp.Buehler@usz.ch

Philipp K Buehler, MD, Principal Investigator
Institute of Intensive Care Medicine, University Hospital Zurich

University of Zurich
NCT Number
Keywords
lung mechanics
heart-lung interaction
MeSH Terms
COVID-19
Respiratory Distress Syndrome
Respiratory Distress Syndrome, Newborn
Acute Lung Injury