This study is meant to assess the lung mechanics in SARS-CoV-2 induced acute respiratory failure. A precise characterisation of lung mechanics and heart-lung-interactions might allow a better understanding of SARS-CoV-2 induced acute respiratory failure and thus lead to better mechanical ventilation strategies. This monocentric, observational study of critically ill COVID-19 patients in the ICU, will employ impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry as well as classic mechanical ventilation parameters to characterise the mechanical characteristics of the lung as well as the heart-lung interactions in SARS-CoV-2 induced acute respiratory failure.
Diagnostic Test: Assessment of lung mechanics and heart-lung interactions
Impedance tomography, right-heart catheterization, oesophageal pressure measurements, indirect calorimetry and classic mechanical ventilation parameters
Inclusion Criteria:
- SARS-CoV-2 infection
- Moderate to Severe ARDS after Berlin Classification at PEEP 5
- Admission to the Institute of Intensive Care of the University Hospital Zurich
- Invasive Mechanical Ventilation
- Signed Study Informed Consent or emergency procedure according to article 30 HFG
Exclusion Criteria:
- Pregnant or breast feeding patients
- Age <18 years
- Presumed rejection of the study intervention
Institute of Intensive Care Medicine, University Hospital Zurich
Zurich, Switzerland
Investigator: Philipp K Buehler, MD
philipp.buehler@usz.ch
Philipp K Buehler, MD
+41 43 25 31340
Philipp.Buehler@usz.ch
Philipp K Buehler, MD, Principal Investigator
Institute of Intensive Care Medicine, University Hospital Zurich