Time to recover of Anosmia and / or ageusia and early corticosteroid use
In a study of dexamethasone kinetics in two groups of 15 patients with community-acquired
pneumonia, one group was treated with dexamethasone 6 mg/day by mouth and the other with 4
mg/day intravenously. The apparent volume of distribution was 1 L/kg in both groups, but the
half-life after oral administration was approximately 7 hours, and after intravenous
administration 9 hours. The bioavailability of oral dexamethasone was 81% (95% CI = 54-121%).
However, the biological half-life of dexamethasone is much longer, of the order of 36-54 h
compared with 18-36 h for prednisolone.
Time to recover of Anosmia and / or ageusia and early corticosteroid use
Drug: Early-Dexamethasone
early use of dexamethasone as early as laboratory evidence of high inflammatory markers
Other Name: Dexamethasone
Drug: Late dexamethazone
Use of dexamethasone on deterioration of the cases with increased severity
Other Name: Dexamethasone
Inclusion Criteria:
- Any case with COVID-19
- Age more than or equal to 18 years
- Mild to moderate severity
Exclusion Criteria:
- Diabetes
- Any contra-indication for the interventional drug
- Mentally disabled cases
Asalam
Maadi, Cairo, Egypt
Investigator: Emad R Issak, MD
Contact: 01272228989
dr.emad.r.h.issak@gmail.com
Emad R Issak, MD
01272228989
dr.emad.r.h.issak@gmail.com
Emad R Issak, MD, Study Director
Assalam Clinics