The actual COVID-19 epidemy is an unprecedented healthcare problem. Although acute respiratory distress syndrome is the main organ failure, acute kidney injury (AKI) has appeared to be more frequent and more severe than expected. Some data suggested a potential direct renal tropism of the virus, or undirect injury by "cytokine storm". The aims of this study are: 1. To describe incidence, severity and mortality associated with AKI during covid-19 infection in ICU 2. To identify specific risk factors for AKI 3. To explore pathophysiologic mechanism of AKI during COVID-19 infection
Other: Non interventional study
Comorbidities, creatinine levels, urinary analysis, hemodynamic, respiratory status, co-medication will be collected from medical files for each patient.
Specific datas from patients with AKI will be collected from medical files For severe acute patients, serum and urinary analysis will performed to identify the underlying cause of kidney injury For severe AKI patients who will die, post-mortem renal biopsy will be performed, for histopathological analysis
Inclusion Criteria:
- Confirmed COVID-19 infection (by qRT-PCR and/or TDM typical lesion)
- Needing intensive care
Exclusion Criteria:
- End Stage Renal Disease patients (with pre-existent dialysis)
- Intensive care support for less than 72h (transfer in conventional unit or death)
Intensive care units attached to the Hospices Civils de Lyon (HCL)
Lyon, France
Investigator: Denis FOUQUE, Professor
Contact: +33 472 678 704
denis.fouque@chu-lyon.fr
Denis FOUQUE, Professor
+33 472 678 704
denis.fouque@chu-lyon.fr
Maxime ESPI
+33 472 678 704
maxime.espi@chu-lyon.fr