Official Title
Zinc Versus Multivitamin Micronutrient Supplementation to Support Immune Health in the Setting of COVID-19 Pandemic: A Randomized Study
Brief Summary

The purpose of this research study is to look at high dose zinc versus multivitamin micronutrient supplementation to support immune health in the setting of the COVID-19 pandemic.

Detailed Description

This is a two-cohort prospective randomized study intended to test the role of Zinc versus multivitamin supplementation in supporting immune health in the setting of the COVID-19 pandemic. Individuals over 50 years old or primary health care professionals over the age of 18 who have had no evidence of prior COVID-19 infection and who have been asymptomatic for 7 days prior to enrollment will be randomized at the individual level to take either PreserVision AREDS formulation with 69.6mg/day Zinc supplementation or to receive a Centrum Adult (under 50) multivitamin supplement.

Enrolling by invitation
Healthy
Health Care Worker Patient Transmission
Aging

Dietary Supplement: PreserVision AREDS formulation gel tabs
Two tabs taken daily for three months
High dose Zinc (PreserVision AREDS formulation gel tabs)

Dietary Supplement: Centrum Adult (under 50) multivitamin
One tab taken daily for three months
Centrum Adult (under 50) multivitamin

Eligibility Criteria

Inclusion Criteria:

- Age ≥50 years old OR primary healthcare professional (defined as having a job that has had direct patient contact during the COVID-19 pandemic) and ≥18 years old

- No symptoms of COVID-19 (a fever of 100.0o F or greater, OR a new cough, OR new shortness of breath, OR new sore throat, OR new diarrhea, OR new fast breathing (respiratory distress), OR new chills, OR new muscle aches (myalgias), OR new loss of smell, OR new change or loss of taste sensation) in the past 7 days

- Have a negative Elecsys Anti-SARS-CoV-2 immunoassay antibody test at screening

- Have not had close contact with a person with a LABORATORY CONFIRMED case of COVID-19 (Close contact is defined by CDC as: Being within approximately 6 feet of a COVID-19 patient for a prolonged period of time (more than 5 minutes) or having direct contact with infectious secretions of a COVID-19 patient (e.g. being coughed on)) in the last 14 days

- Mayo Clinic patient who has a patient online account set up or is willing to set up an online account

- Must have a valid email address and internet service

Exclusion Criteria:

- History of positive or indeterminate COVID PCR test prior to screening or Elecsys Anti-SARS-CoV-2 immunoassay antibody test positive or indeterminate at screening

- Active symptoms of COVID ((a fever of 100.0o F or greater, OR a new cough, OR new shortness of breath, OR new sore throat, OR new diarrhea, OR new fast breathing (respiratory distress), OR new chills, OR new muscle aches (myalgias), OR new loss of smell, OR new change or loss of taste sensation)) in past 7 days

- Known intolerance to Centrum multivitamins or Zinc supplement from prior exposure

- Inability to complete follow-up questions or grant access to electronic health record for surveillance

- Have had close contact with a person with a LABORATORY CONFIRMED case of COVID-19 in past 14 days

- Current or former smoker less than 5 years ago

- Pregnant or breastfeeding

- Prisoner

- Any subject with known immunosuppressed state, including 1. A history of solid organ or bone marrow transplantation 2. Subjects currently receiving chemotherapy 3. Current rheumatologic or autoimmune illness requiring treatment with glucocorticoids, antimetabolite agents (methotrexate, azathioprine, mercaptopurine, fluorouracil, mycophenolate, leflunomide), IMIDs (lenalidomide, thalidomide, pomalidomide), calcineurin inhibitors (tacrolimus, cyclosporine), mTOR inhibitors (sirolimus, everolimus), or any monoclonal antibody drugs (including any drug given intravenously or subcutaneously) for the purpose of immunosuppression 4. Subjects with HIV or primary immunodeficiency syndromes

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years~Maximum: 90 Years
Countries
United States
Locations

Mayo Clinic in Rochester
Rochester, Minnesota, 55905

Atta Behfar, MD, PhD
Principal Investigator
Mayo Clinic

NCT Number
Keywords
Zinc
Immune health