Official Title
Safety and Immunogenicity of Oxford AstraZeneca Vaccine in Zagazig University Hospital Health-care Workers
Brief Summary

After SARS-COV-2 inactivated vaccine authorization for use in different countries including Egypt, investigating its immunogenicity, safety, and efficacy in preventing COVID-19 infection is highly needed. In Egypt, immunization of HCWs in isolation hospitals by SARS-COV-2 inactivated vaccine is now a national priority. Moreover, data and reports regarding the application of vaccine are still limited and deficient.

Detailed Description

This study will be conducted at Zagazig University hospital. Laboratory work will be
implemented at Immunology Research Laboratory at Microbiology and Immunology Department,
Faculty of Medicine, Zagazig University. A representative sample will be drawn from
healthcare workers (HCWs) at Zagazig University Hospital. Assessment of inclusion and
exclusion criteria by history taking. Blood samples will be drawn from HCWs by direct
venipuncture before the start of immunization and 14 days after immunization. The incidence
of any adverse reactions after each immunization will be recorded. SARS-CoV-2 neutralizing
antibodies will be detected by enzyme-linked immunosorbent assay.

Completed
Vaccine Adverse Reaction
Seroconversion

Biological: SARS-Cov-2 neutralizing antibody titer

Quantitation of SARS-Cov-2 antibody titer at baseline after each dose of the vaccine

Eligibility Criteria

Inclusion Criteria:

-Healthy healthcare workers

Exclusion Criteria:

- Healthy healthcare workers' refusal.

- Pregnancy and lactation.

- Confirmed acute cases of SARS-CoV-2 Infection

- Having a history of SARS-CoV-2 infection in the past 3 months.

- Fever (body temperature > 37.0 ℃), dry cough, fatigue, nasal obstruction, runny nose,
pharyngeal pain, myalgia, diarrhea, shortness of breath and dyspnea occurred within 14
days before vaccination.

- History of allergy to any vaccines

- Previous vaccination within the last 30 days

Eligibility Gender
All
Eligibility Age
Minimum: 18 Years ~ Maximum: N/A
Countries
Egypt
Locations

Zagazig University Faculty of Medicine
Zagazig, Sharkia, Egypt

Noha M Hammad, MD, Principal Investigator
Faculty of Medicine, Zagazig University , Zagazig, Egypt

Zagazig University
NCT Number
MeSH Terms
Antibodies
Antibodies, Blocking