Coronavirus disease 2019 (Covid-19) is now a leading cause of death among U.S. adults. In addition to profound respiratory and multi-organ failure, hypercoagulable states and venous thromboembolism (VTE) have been increasingly reported in patients with severe Covid-19. The aim of this study is evaluate the risk of VTE related to Covid-19 infection in a real-world community-based population.
This is an observational study of adult (age ≥18 years) members enrolled in the Kaiser
Permanente Northern California (KPNC) or Kaiser Permanente Southern California (KPSC)
integrated healthcare delivery systems during the time period January 1, 2020 through January
31, 2021, (representing the first year of the Covid-19 pandemic) and diagnosed with incident
Covid-19. The outcomes will be incident VTE and all-cause death, assessed through February
28, 2021. The primary analysis will describe the rate of post-Covid-19 VTE after index
diagnosis. A second analysis will compare the risk of VTE in hospitalized patients with
Covid-19 compared with matched hospitalized controls without Covid-19.
Other: Laboratory test positive for SARS-CoV-2 virus
Exposure/intervention: diagnosis of Covid-19, defined as positive laboratory test for SARS-CoV-2
Inclusion
- Covid-19 diagnosis (defined as date of a positive laboratory test for SARS-CoV-2
virus) during the time period January 1, 2020 to January 31, 2021
- Age >=18 years
- Continuous pharmacy benefits and health plan membership for at least 12 months before
the index date
Exclusion
• incomplete information on age and sex
Kaiser Permanente Northern California
Oakland, California, United States
Kaiser Permanente Southern California
Pasadena, California, United States
Margaret C Fang, MD, Principal Investigator
University of California, San Francisco